Protein Family Models

This domain is often found next to the Pfam:PF02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand [1]. The domain is predicted to adopt an all beta structure [1]. [1]. 11292341. Regulatory potential, phyletic distribution and evolution of. ancient, intracellular small-molecule-binding domains.. Anantharaman V, Koonin EV, Aravind L;. J Mol Biol 2001;307:1271-1292. (from Pfam)

Date:

2024-08-14

This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 (Swiss:P35523) is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney [3]. These proteins contain two Pfam:PF00571 domains. [1]. 9252364. Reconstitution of functional voltage-gated chloride channels. from complementary fragments of CLC-1.. Schmidt-Rose T, Jentsch TJ;. J Biol Chem 1997;272:20515-20521.. [2]. 8857733. Mutations in the human skeletal muscle chloride channel gene. (CLCN1) associated with dominant and recessive myotonia. congenita.. Zhang J, George AL Jr, Griggs RC, Fouad GT, Roberts J,. Kwiecinski H, Connolly AM, Ptacek LJ;. Neurology 1996;47:993-998.. [3]. 11182894. ClC chloride channels.. Mindell JA, Maduke M;. Genome Biol 2001;2:REVIEWS3003. (from Pfam)

Date:

2024-08-14

ClC family H(+)/Cl(-) exchange transporter mediates extreme acid resistance response in eubacteria and archaea, similar to Escherichia coli ClC chloride channel EriC, which can counterbalance the electric current produced by the outwardly directed virtual proton pump linked to amino acid decarboxylation

Date:

2021-02-04