Protein Family Models for Protein (Select 446362330) - Protein Family Models

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Items: 4

Select item 4142341.

4-hydroxythreonine-4-phosphate dehydrogenase PdxA

In Escherichia coli the coenzyme pyridoxal 5'-phosphate is synthesised de novo by a pathway that is thought to involve the condensation of 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose, catalysed by the enzymes PdxA and PdxJ, to form either pyridoxine (vitamin B6) or pyridoxine 5'-phosphate [1]. [1]. 10225425. Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein. Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS;. FEBS Lett 1999;449:45-48. (from Pfam)

GO Terms:

Molecular Function:: NAD binding (GO:0051287)

Date:: 2024-10-16

Family Accession:: NF016084.5
Method:: HMM

Select item 3938072.

new record, indexing in progress

Family Accession:

Select item 3508363.

new record, indexing in progress

Family Accession:

Select item 1760864.

PdxA family protein

PdxA family protein similar to 4-hydroxythreonine-4-phosphate dehydrogenase that catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 3-amino-2-oxopropyl phosphate