Protein Family Models

This family includes class II aldolases and adducins which have not been ascribed any enzymatic function. [1]. 8515438. The spatial structure of the class II L-fuculose-1-phosphate aldolase from Escherichia coli. Dreyer MK, Schulz GE;. J Mol Biol 1993;231:549-553. [2]. 8676381. Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure. Dreyer MK, Schulz GE;. J Mol Biol 1996;259:458-466. (from Pfam)

Date:

2024-10-16

L-fuculose-phosphate aldolase catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde; Also able to catalyze the reversible cleavage of D-ribulose 1-phosphate, but FucA has a higher affinity for L-fuculose 1-phosphate and L-lactaldehyde than for D-ribulose 1-phosphate and glycolaldehyde, respectively

Date:

2021-01-18

Catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate

Date:

2020-10-26

Members of this family are L-fuculose phosphate aldolase from various Proteobacteria, encoded in fucose utilization operons. Homologs in other bacteria given similar annotation but scoring below the trusted cutoff may share extensive sequence similarity but are not experimenally characterized and are not found in apparent fucose utilization operons; we consider their annotation as L-fuculose phosphate aldolase to be tenuous. This model has been narrowed in scope from the previous version.

Gene:

fucA

Date:

2024-05-29