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aldo/keto reductase
This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2]. [1]. 8234324. Refined 1.8 A structure of human aldose reductase complexed with. the potent inhibitor zopolrestat.. Wilson DK, Tarle I, Petrash JM, Quiocho FA;. Proc Natl Acad Sci U S A 1993;90:9847-9851.. [2]. 10884227. Structure of the cytoplasmic beta subunit-T1 assembly of. voltage-dependent K+ channels.. Gulbis JM, Zhou M, Mann S, MacKinnon R;. Science 2000;289:123-127. (from Pfam)
aldo/keto reductase (AKR) is a soluble NAD(P)(H) oxidoreductase that catalyzes the reduction of aldehydes and ketones to their corresponding primary and secondary alcohols
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