Protein Family Models

This family consists of various hypothetical proteins and an l-lysine exporter LysE Swiss:P94633 from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators [1]. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times [1]. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine [1]. [1]. 8971704. A new type of transporter with a new type of cellular function: L- lysine export from Corynebacterium glutamicum. Vrljic M, Sahm H, Eggeling L;. Mol Microbiol 1996;22:815-826. [2]. 10322417. A new family of amino-acid-efflux proteins. Aleshin VV, Zakataeva NP, Livshits VA;. Trends Biochem Sci 1999;24:133-135. (from Pfam)

Date:

2024-10-16

leucine efflux protein exports leucine; can also transport its natural analog L-alpha-amino-N-butyric acid and some other structurally unrelated amino acids

Date:

2015-10-01

Gene:

leuE

Date:

2021-08-16