Protein Family Models

This family includes both hybrid-cluster proteins and the beta chain of carbon monoxide dehydrogenase. The hybrid-cluster proteins contain two Fe/S centres - a [4Fe-4S] cubane cluster, and a hybrid [4Fe-2S-2O] cluster. The physiological role of this protein is as yet unknown, although a role in nitrate/nitrite respiration has been suggested [1]. The prismane protein from Escherichia coli was shown to contain hydroxylamine reductase activity (NH2OH + 2e + 2 H+ -> NH3 + H2O). This activity is rather low. Hydroxylamine reductase activity was also found in CO-dehydrogenase in which the active site Ni was replaced by Fe [2]. The CO dehydrogenase contains a Ni-3Fe-2S-3O centre. [1]. 10651802. The hybrid-cluster protein ('prismane protein') from Escherichia coli. Characterization of the hybrid-cluster protein, redox properties of the [2Fe-2S] and [4Fe-2S-2O] clusters and identification of an associated NADH oxidoreductase containing FAD and [2F. van den Berg WA, Hagen WR, van Dongen WM;. Eur J Biochem 2000;267:666-676. [2]. 12374823. Hydroxylamine reductase activity of the hybrid cluster protein from Escherichia coli. Wolfe MT, Heo J, Garavelli JS, Ludden PW;. J Bacteriol 2002;184:5898-5902. (from Pfam)

Date:

2024-10-16

Has hydroxylamine reductase activity, catalyzes the reduction of hydroxylamine to ammonia and water

Gene:

hcp

Date:

2021-07-30

This HMM represents a family of proteins containing an unusual 4Fe-2S-2O hydrid cluster. Earlier reports had proposed a 6Fe-6S prismane cluster. This subfamily is heterogeneous with respect to the presence or absence of a region of about 100 amino acids not far from the N-terminus of the protein. Members have been described as monomeric. The general function is unknown, although members from E. coli and several other species have hydroxylamine reductase activity. Members are found in various bacteria, in Archaea, and in several parasitic eukaryotes: Giardia intestinalis, Trichomonas vaginalis, and Entamoeba histolytica.

Gene:

hcp

Date:

2024-05-29

hydroxylamine reductase contains a hybrid [Fe4-S2-O2] cluster and catalyzes the reduction of hydroxylamine to form ammonia and water

Date:

2018-08-28