Protein Family Models

The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella [1]. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats). [1]. 11266368. An inner membrane platform in the type II secretion machinery of Gram-negative bacteria. Py B, Loiseau L, Barras F;. EMBO Rep 2001;2:244-248. [2]. 15223057. The general secretory pathway: a general misnomer?. Desvaux M, Parham NJ, Scott-Tucker A, Henderson IR;. Trends Microbiol. 2004;12:306-309. [3]. 14600218. Type II protein secretion and its relationship to bacterial type IV pili and archaeal flagella. Peabody CR, Chung YJ, Yen MR, Vidal-Ingigliardi D, Pugsley AP, Saier MH Jr;. Microbiology. 2003;149:3051-3072. [4]. 19299134. Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue. Desvaux M, Hebraud M, Talon R, Henderson IR;. Trends Microbiol. 2009;17:139-145. (from Pfam)

Date:

2024-10-16

Members of this family occur in Gram-positive bacteria as part of a type IV pilus system used for DNA binding and uptake when species such as Streptococcus pneumoniae or Bacilus subtilis are in a competent state for natural transformation. Members of this family, typically called ComGB (second protein of the ComG operon), belong more broadly to the family of GspF, part of type 2 secretion systems (T2SS) in Gram-negative bacteria.

Gene:

comGB

Date:

2022-07-13