Protein Family Models

Date:

2024-08-14

The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops. [1]. 12208506. Domain structure and ATP-induced conformational changes in Escherichia coli protease Lon revealed by limited proteolysis and autolysis. Vasilyeva OV, Kolygo KB, Leonova YF, Potapenko NA, Ovchinnikova TV;. FEBS Lett 2002;526:66-70. (from Pfam)

Date:

2024-10-16

PDZ domains are found in diverse signaling proteins. Review article. [1]. 9204764. PDZ domains: targeting signalling molecules to sub-membranous sites. Ponting CP, Phillips C, Davies KE, Blake DJ. Bioessays 1997;19:469-479. [2]. 8674113. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R;. Cell. 1996;85:1067-1076. Extension of PDZ family. [3]. 9041651. Evidence for PDZ domains in bacteria, yeast, and plants. Ponting CP;. Protein Sci 1997;6:464-468. [4]. 19738200. Rapid evolution of functional complexity in a domain family. Ernst A, Sazinsky SL, Hui S, Currell B, Dharsee M, Seshagiri S, Bader GD, Sidhu SS;. Sci Signal. 2009;2:ra50. (from Pfam)

Date:

2024-10-16

This HMM describes a peptide pheromone-processing S16-type serine protease found broadly in Gram-positive bacteria, and named for the founding member from Streptococcus mutans (see BlastRule NBR014542). The Lon-like catalytic domain is located toward the C-terminus, and has a Ser-Lys active site dyad rather than the more common Ser-His-Asp triad found in large numbers of serine proteases. Members of this family also have a PDZ domain.

Date:

2022-12-21

PDZ domain-containing protein similar to Bacillus subtilis YlbL, which belongs to the peptidase S16 family

Date:

2017-07-17