Protein Family Models for Protein (Select 446403528) - Protein Family Models

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Links from Protein

Items: 5

Select item 4221831.

DUF4130 domain-containing protein

Date:: 2024-08-14

Family Accession:: NF024955.5
Method:: HMM

Select item 3999562.

new record, indexing in progress

Family Accession:

Select item 3583253.

new record, indexing in progress

Family Accession:

Select item 2134174.

TIGR03915 family putative DNA repair protein

TIGR03915 family putative DNA repair protein containing a DUF4130 domain

Date:: 2020-08-13

Family Accession:: 10024063
Method:: Sparcle

Select item 1482195.

TIGR03915 family putative DNA repair protein

This HMM represents a conserved hypothetical protein that almost invariably pairs with an uncharacterized radical SAM protein. The pair occurs in about twenty percent of completed prokaryotic genomes. About forty percent of the members of this family occur as fusion proteins, where the C-terminal domain belongs to the uracil-DNA glycosylase family, a DNA repair family (because uracil in DNA is deamidated cytosine). The linkage by gene clustering and correlated species distribution to a radical SAM protein, and by gene fusion to a DNA repair protein family, suggests a role in DNA modification and/or repair.