Protein Family Models for Protein (Select 446443419) - Protein Family Models

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Links from Protein

Items: 6

Select item 4119261.

This family uses S-AdoMet in the methylation of diverse substrates. This family includes a related group of bacterial proteins of unknown function, including Swiss:P45528. This family includes the methylase Dipthine synthase. (from Pfam)

GO Terms:

Molecular Function:: methyltransferase activity (GO:0008168)

Date:: 2024-08-14

Family Accession:: NF012799.5
Method:: HMM

Select item 3892112.

new record, indexing in progress

Family Accession:

Select item 3467603.

new record, indexing in progress

Family Accession:

Select item 1419894.

uroporphyrinogen-III C-methyltransferase

This HMM represents enzymes, or enzyme domains, with uroporphyrin-III C-methyltransferase activity. This enzyme catalyzes the first step committed to the biosynthesis of either siroheme or cobalamin (vitamin B12) rather than protoheme (heme). Cobalamin contains cobalt while siroheme contains iron. Siroheme is a cofactor for nitrite and sulfite reductases and therefore plays a role in cysteine biosynthesis; many members of this family are CysG, siroheme synthase, with an additional N-terminal domain and with additional oxidation and iron insertion activities.

Gene:: cobA

GO Terms:

Molecular Function:: uroporphyrin-III C-methyltransferase activity (GO:0004851)

Biological Process:: siroheme biosynthetic process (GO:0019354)

Date:: 2021-04-27

Family Accession:: TIGR01469.1
Method:: HMM

Select item 1364575.

uroporphyrinogen-III C-methyltransferase

uroporphyrinogen-III C-methyltransferase catalyzes two sequential methylation reactions (on C2 and C7) of uroporphyrinogen-III (UROGEN) to yield precorrin-2