Protein Family Models

This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyse the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage [1-3]. [1]. 21757685. RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo. Tanaka N, Meineke B, Shuman S;. J Biol Chem. 2011;286:30253-30257. [2]. 21224389. RtcB is the RNA ligase component of an Escherichia coli RNA repair operon. Tanaka N, Shuman S;. J Biol Chem. 2011;286:7727-7731. [3]. 21311021. HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Popow J, Englert M, Weitzer S, Schleiffer A, Mierzwa B, Mechtler K, Trowitzsch S, Will CL, Luhrmann R, Soll D, Martinez J;. Science. 2011;331:760-764. (from Pfam)

Date:

2024-10-16

RtcB family protein similar to RNA-splicing ligase RtcB, which repairs tRNA damage by directly joining spliced tRNA halves to mature-sized tRNAs

Date:

2016-01-19

Members of this family are related to RctB. RctB a protein of known structure but unknown function that often is encoded near RNA cyclase and therefore is suggested to be a tRNA or mRNA processing enzyme. This family of RctB-like proteins in encoded upstream of, and apparently is translationally coupled to, the putative peptide chain release factor RF-H (TIGR03072), product of the prfH gene. Note that a large deletion at the junction between this gene and the prfH gene in Escherichia coli K-12 marks both as probable pseudogenes.

Date:

2024-08-07

Date:

2021-10-18