Protein Family Models

The AIDA repeat is found on bacterial autotransporter proteins. As the repeat is short and occurs multiple times, it is likely to be the region of the transporter that acts as the stalk between the beta-barrel inserted into the membrane and the N-terminal head domain. [1]. 15547278. Novel roles for the AIDA adhesin from diarrheagenic Escherichia coli: cell aggregation and biofilm formation. Sherlock O, Schembri MA, Reisner A, Klemm P;. J Bacteriol. 2004;186:8058-8065. [2]. 15950405. Characterization and immuno-detection of AIDA-I adhesin isolated from porcine Escherichia coli. Fang Y, Ngeleka M, Middleton DM, Simko E;. Vet Microbiol. 2005;109:65-73. [3]. 1625582. AIDA-I, the adhesin involved in diffuse adherence of the diarrhoeagenic Escherichia coli strain 2787 (O126:H27), is synthesized via a precursor molecule. Benz I, Schmidt MA;. Mol Microbiol. 1992;6:1539-1546. [4]. 22466966. Discovery of an archetypal protein transport system in bacterial outer membranes. Selkrig J, Mosbahi K, Webb CT, Belousoff MJ, Perry AJ, Wells TJ, Morris F, Leyton DL, Totsika M, Phan MD, Celik N, Kelly M, Oates C, Hartland EL, Robins-Browne RM, Ramarathinam SH, Purcell AW, Schembri MA, Strugnell RA, Henderson IR, Walker D, Lithgow T;. Nat Struct Mol Biol. 2012;19:506-510. [5]. 15123066. Bugs and the gut: an unstable marriage. Farthing MJ;. Best Pract Res Clin Gastroenterol. 2004;18:233-239. (from Pfam)

Date:

2024-10-16

Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease [2]. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs [1]. [1]. 9778731. The great escape: structure and function of the autotransporter proteins. Henderson IR, Navarro-Garcia F, Nataro JP;. Trends Microbiol 1998;6:370-378. [2]. 3027577. Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Pohlner J, Halter R, Beyreuther K, Meyer TF;. Nature 1987;325:458-462. [3]. 11980709. Export of autotransported proteins proceeds through an oligomeric ring shaped by C-terminal domains. Veiga E, Sugawara E, Nikaido H, de Lorenzo V, Fernandez LA;. EMBO J 2002;21:2122-2131. [4]. 15014442. Structure of the translocator domain of a bacterial autotransporter. Oomen CJ, Van Ulsen P, Van Gelder P, Feijen M, Tommassen J, Gros P;. EMBO J 2004;23:1257-1266. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus.

Date:

2024-06-21

protein containing domains PRK09945, PL1_Passenger_AT, and PL_Passenger_AT

Date:

2019-03-21

This model describes two tandem copies of a strand-loop-strand repeat that occurs often in type V secretion system (T5SS). These repeats usually occur in the passenger domain of the classical monomeric autotransporter. Proteins with this repeat often are encoded next to a member of family TIGR04414, the Aah/TibC family O-heptosyltransferase, and may be glycosylated in regions with this repeat.

Date:

2020-10-23

YejO, as found in many strains of Escherichia coli, is an uncharacterized autotransporter that may be an adhesin.

Gene:

yejO

Date:

2021-07-17