Protein Family Models

This domain is found in peptide chain release factors such as RF-1 (Swiss:P07011) and RF-2 (Swiss:P07012), and a number of smaller proteins of unknown function such as Swiss:P40711. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis. [1]. 10676813. The crystal structure of human eukaryotic release factor. eRF1--mechanism of stop codon recognition and peptidyl-tRNA. hydrolysis.. Song H, Mugnier P, Das AK, Webb HM, Evans DR, Tuite MF, Hemmings. BA, Barford D;. Cell 2000;100:311-321. (from Pfam)

Date:

2024-08-14

ArfB (alternative ribosome rescue factor B), a peptidyl-tRNA hydrolase, represents a separate ribosome rescue system from the tmRNA-mediated trans-translation system and the ArfA and PrfB alternative ribosome rescue system. In some species, ArfB enables survival when both the tmRNA and ArfA systems are disabled.

Gene:

arfB

Date:

2022-08-26

aminoacyl-tRNA hydrolase similar to Escherichia coli ArfB, alternative ribosome rescue factor B, a peptide chain release factor which functions as a stalled-ribosome rescue factor

Date:

2023-03-21