Protein Family Models

This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF01588. (from Pfam)

Date:

2024-08-14

This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1) [2], human tyrosyl-tRNA synthetase [1], and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases [2]. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme [2]. This domain may perform a common function in tRNA aminoacylation [1]. [1]. 9162081. Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine. Kleeman TA, Wei D, Simpson KL, First EA;. J Biol Chem 1997;272:14420-14425. [2]. 8895587. The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl-and glutamyl-tRNA synthetases. Simos G, Segref A, Fasiolo F, Hellmuth K, Shevchenko A, Mann M, Hurt EC;. EMBO J 1996;15:5437-5448. (from Pfam)

Date:

2024-10-16

Gene:

ytpR

Date:

2024-03-01

DUF4479 and tRNA-binding domain-containing protein

Date:

2019-10-28