Protein Family Models for Protein (Select 446501024) - Protein Family Models

Select item 4359901.

helix-turn-helix domain-containing protein

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator SinR of Bacillus subtilis, which represses biofilm formation by binding to the respective eps promoter

Date:: 2024-04-16

Family Accession:: 11443820
Method:: Sparcle

Select item 4255742.

helix-turn-helix domain-containing protein

This is a helix-turn-helix domain that probably binds to DNA. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024835.5
Method:: HMM

Select item 4237293.

helix-turn-helix domain-containing protein

Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024252.5
Method:: HMM

Select item 4223214.

helix-turn-helix domain-containing protein

This domain is a helix-turn-helix domain that probably binds to DNA. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024949.5
Method:: HMM

Select item 4186225.

DNA-binding anti-repressor SinI

SinR is a pleiotropic regulator of several late growth processes. It is a tetrameric DNA binding protein whose activity is down-regulated thorough the formation of a SinI:SinR protein complex. When complexed with SinI, the SinR tetramer is disrupted such that is no longer able to bind DNA. [1]. 8422983. SinI modulates the activity of SinR, a developmental switch protein of Bacillus subtilis, by protein-protein interaction. Bai U, Mandic-Mulec I, Smith I;. Genes Dev. 1993;7:139-148. [2]. 8549812. Crystallisation of the Bacillus subtilis sporulation inhibitor SinR, complexed with its antagonist, SinI. Lewis RJ, Brannigan JA, Smith I, Wilkinson AJ;. FEBS Lett. 1996;378:98-100. (from Pfam)

Gene:: sinI

GO Terms:

Biological Process:: regulation of DNA-templated transcription (GO:0006355)

Molecular Function:: protein dimerization activity (GO:0046983)

Date:: 2024-10-16

Family Accession:: NF020255.5
Method:: HMM

Select item 4125446.

helix-turn-helix domain-containing protein

This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1]. [1]. 20196080. The crystal structure of NGO0477 from Neisseria gonorrhoeae reveals a novel protein fold incorporating a helix-turn-helix motif. Ren J, Sainsbury S, Nettleship JE, Saunders NJ, Owens RJ;. Proteins. 2010;78:1798-1802. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF013540.5
Method:: HMM

Select item 4019577.