Protein Family Models

Present in all three domains of cellular life. Four copies in the transcriptional coactivator p100: these, however, appear to lack the active site residues of Staphylococcal nuclease. Positions 14 (Asp-21), 34 (Arg-35), 39 (Asp-40), 42 (Glu-43) and 110 (Arg-87) [SNase numbering in parentheses] are thought to be involved in substrate-binding and catalysis. [1]. 9041650. P100, a transcriptional coactivator, is a human homologue of staphylococcal nuclease. Ponting CP;. Protein Sci 1997;6:459-463. [2]. 9003410. The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development. Callebaut I, Mornon JP;. Biochem J 1997;321:125-132. (from Pfam)

Date:

2024-10-16

thermonuclease family protein, may be a thermostable nuclease and catalyze the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond

Date:

2024-07-23