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site-2 protease family protein
stage IV sporulation intramembrane metalloprotease SpoIVFB
SpoIVFB, as found in Bacillus subtilis, is an intramembrane metalloprotease that cleaves and activates the final sigma factor of endospore formation, sigma(K). The characteristic HEXXH motif of metalloproteases occurs within a transmembrane segment.
M50 family metallopeptidase
M50 family metallopeptidase that cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms; belongs to the site-2 protease (S2P) class of zinc metalloproteases
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