Protein Family Models for Protein (Select 446524770) - Protein Family Models

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Items: 4

Select item 4119961.

peptide chain release factor-like protein

This domain is found in peptide chain release factors such as RF-1 (Swiss:P07011) and RF-2 (Swiss:P07012), and a number of smaller proteins of unknown function such as Swiss:P40711. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis. [1]. 10676813. The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis. Song H, Mugnier P, Das AK, Webb HM, Evans DR, Tuite MF, Hemmings BA, Barford D;. Cell 2000;100:311-321. (from Pfam)

GO Terms:

Molecular Function:: translation release factor activity (GO:0003747)

Biological Process:: translational termination (GO:0006415)

Date:: 2024-10-16

Family Accession:: NF012684.5
Method:: HMM

Select item 3888412.

new record, indexing in progress

Family Accession:

Select item 3465003.

new record, indexing in progress

Family Accession:

Select item 528074.

peptide chain release factor H

Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon.