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methyltransferase domain-containing protein
This family appears to have methyltransferase activity. (from Pfam)
This family appears to be a methyltransferase domain. (from Pfam)
tRNA (Uracil-5-)-methyltransferase
This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalysed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity [1]. [1]. 12003492. Dual function of the tRNA(m(5)U54)methyltransferase in tRNA maturation. Johansson MJ, Bystrom AS;. RNA 2002;8:324-335. (from Pfam)
methyltransferase
This domain is found in ribosomal RNA small subunit methyltransferase C (eg Swiss:P44453) as well as other methyltransferases (eg Swiss:Q53742). (from Pfam)
TRAM domain-containing protein
This small domain has no known function. However it may perform a nucleic acid binding role (Bateman A. unpublished observation). [1]. 11313137. TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes. Anantharaman V, Koonin EV, Aravind L;. FEMS Microbiol Lett 2001;197:215-221. (from Pfam)
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD
This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA.
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