Protein Family Models

This domain is found at the C-terminal end of Endoribonuclease YicC from Escherichia coli and similar bacterial sequences. YicC, which is important for cells in the stationary phase, and essential for growth at high temperatures [1], contributes to degradation of the small RNA (sRNA) RhyB via collaboration with the exoribonuclease PNPase [2] and seems to generate a 3'-OH and a 5'-phosphate group [3]. [1]. 1925027. Three genes preceding pyrE on the Escherichia coli chromosome are essential for survival and normal cell morphology in stationary culture and at high temperature. Poulsen P, Jensen KF;. Res Microbiol 1991;142:283-288. [2]. 34210798. A fluorescence-based genetic screen reveals diverse mechanisms silencing small RNA signaling in E. coli. Chen J, To L, de Mets F, Luo X, Majdalani N, Tai CH, Gottesman S;. Proc Natl Acad Sci U S A. 2021;118:e2106964118. [3]. 34815358. Discovery and initial characterization of YloC, a novel endoribonuclease in Bacillus subtilis. Ingle S, Chhabra S, Chen J, Lazarus MB, Luo X, Bechhofer DH;. RNA. 2022;28:227-238. (from Pfam)

Date:

2024-10-16

This domain is found at the N-terminal end of Endoribonuclease YicC from Escherichia coli and similar bacterial sequences. YicC, which is important for cells in the stationary phase, and essential for growth at high temperatures [1], contributes to degradation of the small RNA (sRNA) RhyB via collaboration with the exoribonuclease PNPase [2] and seems to generate a 3'-OH and a 5'-phosphate group [3]. [1]. 1925027. Three genes preceding pyrE on the Escherichia coli chromosome are essential for survival and normal cell morphology in stationary culture and at high temperature. Poulsen P, Jensen KF;. Res Microbiol 1991;142:283-288. [2]. 34210798. A fluorescence-based genetic screen reveals diverse mechanisms silencing small RNA signaling in E. coli. Chen J, To L, de Mets F, Luo X, Majdalani N, Tai CH, Gottesman S;. Proc Natl Acad Sci U S A. 2021;118:e2106964118. [3]. 34815358. Discovery and initial characterization of YloC, a novel endoribonuclease in Bacillus subtilis. Ingle S, Chhabra S, Chen J, Lazarus MB, Luo X, Bechhofer DH;. RNA. 2022;28:227-238. (from Pfam)

Date:

2024-10-16

YloC from Bacillus subtilis and YicC from Escherichia coli K-12 were both shown to act as endonucleases cleaving small RNA molecules.

Date:

2023-05-02