Protein Family Models for Protein (Select 446545096) - Protein Family Models

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Links from Protein

Items: 7

Select item 4363801.

AraC family transcriptional regulator contains a helix-turn-helix DNA-binding motif and controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Date:: 2024-07-23

Family Accession:: 13722860
Method:: Sparcle

Select item 4206772.

helix-turn-helix domain-containing protein

GO Terms:

Molecular Function:: DNA-binding transcription factor activity (GO:0003700)

Biological Process:: regulation of DNA-templated transcription (GO:0006355)

Molecular Function:: sequence-specific DNA binding (GO:0043565)

Date:: 2024-08-14

Family Accession:: NF024242.5
Method:: HMM

Select item 4164773.

AraC family transcriptional regulator N-terminal domain-containing protein

This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains [1]. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating [2]. All family members contain the Pfam:PF00165 domain. [1]. 12683999. Mutational analysis of residue roles in AraC function. Ross JJ, Gryczynski U, Schleif R;. J Mol Biol 2003;328:85-93. [2]. 9600837. Arm-domain interactions in AraC. Saviola B, Seabold R, Schleif RF;. J Mol Biol 1998;278:539-548. (from Pfam)