Protein Family Models

HCP is a family of proteins which are expressed in up to 1000 copies in Gram-negative bacteria. Together these copies aggregate into a needle-like shaft or tube that will penetrate other bacteria via a puncturing protein attached to its head [1]. Initially Hcp forms a hexameric structure with a central channel of 40 Angstroms. These hexamers pile up one on top of each other forming nanotubes resembling the gp19 tail phage tube [2]. [1]. 24381728. The rise of the Type VI secretion system. Filloux A;. F1000Prime Rep. 2013;5:52. [2]. 16763151. A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordonez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ;. Science. 2006;312:1526-1530. (from Pfam)

Date:

2024-10-16

TssD, originally called Hcp1 (hemolysin coregulated protein), forms hexameric ring-shaped structures that stack to form the tube of type VI secretion systems (T6SS).(PMID:17660433). Pathogens may have many multiple members of this family, with three to ten in Erwinia carotovora, Yersinia pestis, uropathogenic Escherichia coli, and the insect pathogen Photorhabdus luminescens.

Gene:

tssD

Date:

2024-08-07

Hcp family type VI secretion system effector acts as a virulence factor, as a transporter of effectors and as a chaperone; it may aggregate into a needle-like shaft that can penetrate other bacteria via a puncturing protein attached to its head

Date:

2021-06-25