Protein Family Models

The LICD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased ability to adhere to host cells and are less virulent [1]. These proteins are part of the nucleotidyltransferase superfamily [2]. [1]. 10200966. Pneumococcal licD2 gene is involved in phosphorylcholine. metabolism.. Zhang JR, Idanpaan-Heikkila I, Fischer W, Tuomanen EI;. Mol Microbiol 1999;31:1477-1488.. [2]. 19833706. Comprehensive classification of nucleotidyltransferase fold. proteins: identification of novel families and their. representatives in human.. Kuchta K, Knizewski L, Wyrwicz LS, Rychlewski L, Ginalski K;. Nucleic Acids Res. 2009; [Epub ahead of print] (from Pfam)

Date:

2024-08-14

phosphorylcholine transferase LicD transfers phosphorylcholine (ChoP) from choline diphosphonucleoside to the lipopolysaccharide (LPS)

Date:

2016-01-20