Protein Family Models

The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan [1]. These proteins are also considered as a factor influencing the level of methicillin resistance [2]. [1]. 9393725. Specificities of FemA and FemB for different glycine residues:. FemB cannot substitute for FemA in staphylococcal peptidoglycan. pentaglycine side chain formation.. Ehlert K, Schroder W, Labischinski H;. J Bacteriol 1997;179:7573-7576.. [2]. 10209768. Molecular characterization of femA from Staphylococcus hominis. and Staphylococcus saprophyticus, and femA-based discrimination. of staphylococcal species.. Vannuffel P, Heusterspreute M, Bouyer M, Vandercam B, Philippe. M, Gala JL;. Res Microbiol 1999;150:129-141.. [3]. 2559314. FemA, a host-mediated factor essential for methicillin. resistance in Staphylococcus aureus: molecular cloning and. characterization.. Berger-Bachi B, Barberis-Maino L, Strassle A, Kayser FH;. Mol Gen Genet 1989;219:263-269.. [4]. 8981974. Cell wall monoglycine cross-bridges and methicillin. hypersusceptibility in a femAB null mutant of. methicillin-resistant Staphylococcus aureus.. Stranden AM, Ehlert K, Labischinski H, Berger-Bachi B;. J Bacteriol 1997;179:9-16.. [5]. 8383661. Influence of femB on methicillin resistance and peptidoglycan. metabolism in Staphylococcus aureus.. Henze U, Sidow T, Wecke J, Labischinski H, Berger-Bachi B;. J Bacteriol 1993;175:1612-1620. (from Pfam)

Date:

2024-08-14

aminoacyltransferase similar to FemABX family of aminoacyltransferases, which catalyze the formation of the pentaglycine interpeptide bridge in S.aureus peptidoglycan and are considered as a factor influencing the level of methicillin resistance

Date:

2023-03-03

FemX, FemA, and FemA together synthesize the interpeptide bridge that crosslinks strands of peptidoglycan as in Staphylococcus aureus.

Gene:

femB

Date:

2017-12-03