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C39 family peptidase
papain-like cysteine protease family protein
This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis [2]. AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defence responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2 [1]. [1]. 10361296. Characterization of the Pseudomonas syringae pv. tomato AvrRpt2 protein: demonstration of secretion and processing during bacterial pathogenesis. Mudgett MB, Staskawicz BJ;. Mol Microbiol. 1999;32:927-941. [2]. 18705889. Papain-like cysteine proteases: key players at molecular battlefields employed by both plants and their invaders. Shindo T, Van der Hoorn RA;. Mol Plant Pathol. 2008;9:119-125. (from Pfam)
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