Protein Family Models

This is a family of proteins that are flavin-dependent thymidylate synthases. [1]. 12029065. An alternative flavin-dependent mechanism for thymidylate synthesis. Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U;. Science. 2002;297:105-107. [2]. 15046578. Two distinct pathways for thymidylate (dTMP) synthesis in (hyper)thermophilic Bacteria and Archaea. Leduc D, Graziani S, Meslet-Cladiere L, Sodolescu A, Liebl U, Myllykallio H;. Biochem Soc Trans. 2004;32:231-235. [3]. 17890305. Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria. Leduc D, Escartin F, Nijhout HF, Reed MC, Liebl U, Skouloubris S, Myllykallio H;. J Bacteriol. 2007;189:8537-8545. (from Pfam)

Date:

2024-10-16

thymidylate synthase catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product

Date:

2017-05-26

Date:

2021-09-22

Members of this protein family are thymidylate synthase, an enzyme that produces dTMP from dUMP. In prokaryotes, its gene usually is found close to that for dihydrofolate reductase, and in some systems the two enzymes are found as a fusion protein. This model excludes a set of related proteins (TIGR03283) that appears to replace this family in archaeal methanogens, where tetrahydrofolate is replaced by tetrahydromethanopterin.

Gene:

thyA

Date:

2024-05-30