Protein Family Models

Many but not all members of this family are formyltransferases or deformylases, including hosphoribosylglycinamide formyltransferase 1 (EC 2.1.2.2), methionyl-tRNA formyltransferase (EC 2.1.2.9), and formyltetrahydrofolate deformylase (EC 3.5.1.1).

Date:

2024-08-14

phosphoribosylglycinamide formyltransferase catalyzes the transfer of a formyl group from lO-formyltetrahydrofolate to glycinamide ribonucleotide

Date:

2022-09-01

This HMM describes phosphoribosylglycinamide formyltransferase (GAR transformylase), one of several proteins in formyl_transf (Pfam family PF00551). This enzyme uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. PurT, a different GAR transformylase, uses ATP and formate rather than formyl tetrahydrofolate. Experimental proof includes complementation of E. coli purN mutants by orthologs from vertebrates (where it is a domain of a multifunctional protein), Bacillus subtilis, and Arabidopsis. No archaeal example was detected. In phylogenetic analyses, the member from Saccharomyces cerevisiae shows a long branch length but membership in the family, while the formyltetrahydrofolate deformylases form a closely related outgroup.

Gene:

purN

Date:

2024-05-30