Protein Family Models

SPI-1 type 3 secretion system secretin forms a ring-shaped multimeric structure which is used to inject bacterial effector proteins into eukaryotic host cells [1-3]. It consists of several N-terminal short domains and a C-terminal secretin domain (Pfam:PF00263). This entry represents the N-terminal N0 domain. Paper describing PDB structure 2y9k. [1]. 21385715. Three-dimensional model of Salmonella's needle complex at subnanometer resolution. Schraidt O, Marlovits TC;. Science. 2011;331:1192-1195. Paper describing PDB structure 3gr5. [2]. 19396170. A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system. Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC;. Nat Struct Mol Biol. 2009;16:468-476. Paper describing PDB structure 3j1v. [3]. 23633951. A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly. Bergeron JR, Worrall LJ, Sgourakis NG, DiMaio F, Pfuetzner RA, Felise HB, Vuckovic M, Yu AC, Miller SI, Baker D, Strynadka NC;. PLoS Pathog. 2013;9:e1003307. Paper describing PDB structure 5tcq. [4]. 27974800. Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body. Worrall LJ, Hong C, Vuckovic M, Deng W, Bergeron JRC, Majewski DD, Huang RK, Spreter T, Finlay BB, Yu Z, Strynadka NCJ;. Nature. 2016;540:597-601. Paper describing PDB structure 6pee. [5]. 31427728. T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly. Hu J, Worrall LJ, Vuckovic M,. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

This is a short, often repeated, domain found in bacterial type II/III secretory system proteins. All previous NolW-like domains fall into this family. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

EscC/YscC/HrcC family type III secretion system outer membrane ring protein similar to Salmonella enterica InvG involved in the invasion of the cells of the intestinal epithelium and Shigella flexneri MxiD necessary for the secretion of the Shigella flexneri lPA invasins

Date:

2019-04-10

This model describes protein SctC, the outer membrane ring protein of the basal body of the type III secretion system (T3SS) as found in many pathogenic bacteria. Lineage-specific names for SctC include YscC (Yersinia), HrcC (Pseudomonas syringae), PscC in Pseudomonas aeruginosa, and InvG and SsaC in Salmonella pathogenicity islands SPI-1 nd SPI-2, respectively. More distant homologs include the secretins PilQ of type IV pilus systems and GspD of type II secretion systems.

Gene:

sctC

Date:

2024-05-30