Protein Family Models

This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyses the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyses the reactions: (S)-malate + NAD(+) <=> oxaloacetate + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively. [1]. 8405966. The Alcaligenes eutrophus ldh structural gene encodes a novel type of lactate dehydrogenase. Jendrossek D, Kratzin HD, Steinbuchel A;. FEMS Microbiol Lett 1993;112:229-235. [2]. 2110059. Properties and primary structure of the L-malate dehydrogenase from the extremely thermophilic archaebacterium Methanothermus fervidus. Honka E, Fabry S, Niermann T, Palm P, Hensel R;. Eur J Biochem 1990;188:623-632. (from Pfam)

Date:

2024-10-16

Catalyzes the formation of oxalurate from ureidoglycolate

Gene:

allD

Date:

2021-10-18

This enzyme converts ureidoglycolate to oxalureate in the non-urea-forming catabolism of allantoin (GenProp0687). The pathway has been characterized in E. coli [1] and is observed in the genomes of Entercoccus faecalis and Bacillus licheniformis.

Gene:

allD

Date:

2021-04-27

ureidoglycolate dehydrogenase (NAD(+)) catalyzes the oxidation of ureidoglycolate to oxalurate, playing a pivotal role as a metabolic branch-point enzyme in nitrogen utilization via the assimilation of allantoin

Date:

2020-10-30