Protein Family Models

This is a family of Rossmann fold oxidoreductases that catalyse NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyses the hydroxylation of L-ornithine at the N5 position [1,2], and L-lysine 6-monooxygenase, which catalyses the hydroxylation of lysine at the N6 position (EC:1.14.13.59) [3]. [1]. 8106324. Cloning and nucleotide sequence of the pvdA gene encoding the pyoverdin biosynthetic enzyme L-ornithine N5-oxygenase in Pseudomonas aeruginosa. Visca P, Ciervo A, Orsi N;. J Bacteriol. 1994;176:1128-1140. [2]. 16233371. dffA gene from Aspergillus oryzae encodes L-ornithine N5-oxygenase and is indispensable for deferriferrichrysin biosynthesis. Yamada O, Na Nan S, Akao T, Tominaga M, Watanabe H, Satoh T, Enei H, Akita O;. J Biosci Bioeng. 2003;95:82-88. [3]. 16461464. A genetic locus required for iron acquisition in Mycobacterium tuberculosis. Krithika R, Marathe U, Saxena P, Ansari MZ, Mohanty D, Gokhale RS;. Proc Natl Acad Sci U S A. 2006;103:2069-2074. (from Pfam)

Date:

2024-10-16

putative histamine N-monooxygenase similar to non-ribosomal peptide synthetase BasC and anguibactin biosynthesis histamine N-monooxygenase AngU

Date:

2021-10-14

Members of this family are involved in synthesizing N-hydroxyhistamine as a precursor to acinetobactin, a siderophore found in Acinetobacter baumannii. Assuming histidine is first decarboxylated to histamine, then hydroxylated, members of this family are histamine N-monooxygenase. The putative histidine decarboxylase is found in the same biosynthetic cluster.

Gene:

basC

Date:

2019-09-10