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dihydroxyacetone kinase subunit DhaK
This is the kinase domain of the dihydroxyacetone kinase family EC:2.7.1.29. (from Pfam)
DhaKLM operon coactivator DhaQ
DhaKLM operon coactivator DhaQ forms a heterotetramer with the transcription factor DhaS that functions as transcriptional regulator in activating the dhaKLM operon upon covalent binding of dihydroxyacetone to DhaQ.
Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form with a phosphoprotein donor related to PTS transport proteins. This family represents a protein, unique to the Firmicutes (low GC Gram-positives), that appears to be a divergent second copy of the K subunit of that complex; its gene is always found in operons with the other three proteins of the complex.
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