Protein Family Models

Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus. (from Pfam)

Date:

2024-08-14

This octapeptide repeat is found in several bacterial proteins. The function of this repeat is unknown. (from Pfam)

Date:

2024-08-14

This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G. [1]. 1390743. Three-dimensional solution structure of the B domain of staphylococcal protein A: comparisons of the solution and crystal structures. Gouda H, Torigoe H, Saito A, Sato M, Arata Y, Shimada I;. Biochemistry 1992;31:9665-9672. (from Pfam)

Date:

2024-10-16

The GA (protein G-related Albumin-binding) module is composed of three alpha helices [1]. This module is found in a range of bacterial cell surface proteins. The GA module from Swiss:Q51911 shows a strong affinity for albumin. [1]. 9086265. Solution structure of the albumin-binding GA module: a versatile bacterial protein domain. Johansson MU, de Chateau M, Wikstrom M, Forsen S, Drakenberg T, Bjorck L. J Mol Biol 1997;266:859-865. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation [1]. This domain may have a general peptidoglycan binding function. The structure of this domain is known [2]. [1]. 1352512. Modular design of the Enterococcus hirae muramidase-2 and Streptococcus faecalis autolysin. Joris B, Englebert S, Chu CP, Kariyama R, Daneo-Moore L, Shockman GD, Ghuysen JM;. FEMS Microbiol Lett 1992;70:257-264. [2]. 10843862. The structure of a LysM domain from E. coli membrane-bound lytic murein transglycosylase D (MltD). Bateman A, Bycroft M;. J Mol Biol 2000;299:1113-1119. (from Pfam)

Date:

2024-10-29

protein containing domains YSIRK_signal, B, PTZ00449, and LysM

Date:

2017-03-02

This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region.

Date:

2021-04-27