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TcpQ domain-containing protein
The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonisation in the disease of cholera. TcpQ is part of an outer membrane complex of the TCP biogenesis apparatus, comprised of TcpC and TcpQ, and the TcpQ is required for proper localisation of TcpC to the outer membrane. The domain is found in other Proteobacterial species apart from Vibrio. [1]. 1358749. TCP pilus biosynthesis in Vibrio cholerae O1: gene sequence of tcpC encoding an outer membrane lipoprotein. Ogierman MA, Manning PA;. FEMS Microbiol Lett. 1992;76:179-184. [2]. 15774863. Identification of a TcpC-TcpQ outer membrane complex involved in the biogenesis of the toxin-coregulated pilus of Vibrio cholerae. Bose N, Taylor RK;. J Bacteriol. 2005;187:2225-2232. (from Pfam)
toxin co-regulated pilus biosynthesis Q family protein
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