Protein Family Models

This protein family includes proteins predominantly found in Gammaproteobacteria, such as YhfG from Escherichia coli. YhfG is a FicA antitoxin homologue (also known as antitoxin EcFicA) that interacts with EcFiT and forms a complex with it. YhfG shows a unique conformation, forming two parallel alpha- helices linked by a 10-residues loop. The structure of the complex shows a highly conserved extended ligand-binding pocket [1]. [1]. 27657533. Crystal Structure of the Escherichia coli Fic Toxin-Like Protein. in Complex with Its Cognate Antitoxin.. Stanger FV, Harms A, Dehio C, Schirmer T;. PLoS One. 2016;11:e0163654. (from Pfam)

Date:

2024-08-14

Date:

2020-10-26

YhfG family protein is a DUF2559 domain-containing protein; similar to Escherichia coli protein YhfG

Date:

2022-03-30