This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerisation domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR [1-2][4][5]. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships [3]. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor [5]. [1]. 12867439. PlmA, a new member of the GntR family, has plasmid maintenance functions in Anabaena sp. strain PCC 7120. Lee MH, Scherer M, Rigali S, Golden JW;. J Bacteriol 2003;185:4315-4325. [2]. 11756427. Subdivision of the helix-turn-helix GntR family of bacterial regulators in the FadR, HutC, MocR, and YtrA subfamilies. Rigali S, Derouaux A, Giannotta F, Dusart J;. J Biol Chem 2002;277:12507-12515. [3]. 15247334. Extending the classification of bacterial transcription factors beyond the helix-turn-helix motif as an alternative approach to discover new cis/trans relationships. Rigali S, Schlicht M, Hoskisson P, Nothaft H, Merzbacher M, Joris B, Titgemeyer F;. Nucleic Acids Res 2004;32:3418-3426. [4]. 16936034. A new GntR family transcriptional regulator in streptomyces coelicolor is required for morphogenesis and antibiotic production and controls transcription of an ABC transporter in response to carbon source. Hillerich B, Westpheling J;. J Bacteriol. 2006;188:7477-7487. [5]. 16925557. The sugar phosphotransfer. TRUNCATED at 1650 bytes (from Pfam)
GO Terms:- Molecular Function:
- DNA-binding transcription factor activity (GO:0003700)
- Biological Process:
- regulation of DNA-templated transcription (GO:0006355)
- Date:
- 2024-10-16