Protein Family Models

This domain is found to the N-terminus of HipA-like proteins. It is also found in isolation in some proteins. (from Pfam)

Date:

2024-08-14

The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species (for example Swiss:P23874). This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis [1]. When expressed alone, it is toxic to bacterial cells [1], but it is usually tightly associated with HipB [2], and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products [2]. [1]. 1715862. Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. Black DS, Kelly AJ, Mardis MJ, Moyed HS;. J Bacteriol 1991;173:5732-5739. [2]. 8021189. Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. Black DS, Irwin B, Moyed HS;. J Bacteriol 1994;176:4081-4091. (from Pfam)

Date:

2024-10-16

type II toxin-antitoxin (TA) system HipA family toxin similar to Escherichia coli HipA, a serine/threonine-protein kinase that phosphorylates Glu-tRNA-ligase (GltX), preventing it from being charged, leading to an increase in uncharged tRNA(Glu), and is also the toxin component of the HipA-HipB TA module

Date:

2019-02-13

Although Pfam models PF07805 and PF07804 currently are called HipA-like N-terminal domain and HipA-like C-terminal domain, respectively, those models hit the central and C-terminal regions of E. coli HipA but not the N-terminal region. This model hits the N-terminal region of HipA and its homologs, and also identifies proteins that lack match regions for PF07804 and PF07805.

Date:

2019-09-10