Protein Family Models for Protein (Select 446734576) - Protein Family Models

Select item 4177411.

Threonyl and Alanyl tRNA synthetase second additional domain

The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain [1]. [1]. 10319817. The structure of threonyl-tRNA synthetase-tRNA(Thr) complex enlightens its repressor activity and reveals an essential zinc ion in the active site. Sankaranarayanan R, Dock-Bregeon AC, Romby P, Caillet J, Springer M, Rees B, Ehresmann C, Ehresmann B, Moras D;. Cell 1999;97:371-381. (from Pfam)

GO Terms:

Molecular Function:: aminoacyl-tRNA ligase activity (GO:0004812)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: tRNA aminoacylation (GO:0043039)

Date:: 2024-10-16

Family Accession:: NF019585.5
Method:: HMM

Select item 4121652.

alanine--tRNA ligase-related protein

Proteins belonging to this family include alanine--tRNA ligases and related smaller proteins such as alanyl-tRNA editing proteins.

GO Terms:

Molecular Function:: nucleotide binding (GO:0000166)

Molecular Function:: alanine-tRNA ligase activity (GO:0004813)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: alanyl-tRNA aminoacylation (GO:0006419)

Date:: 2024-08-14

Family Accession:: NF013570.5
Method:: HMM

Select item 4116203.

DHHA1 domain-containing protein

DHHA1 ( DHH-associated domain) is often found with DHH, and is suggested to have an RNA-binding function.

GO Terms:

Molecular Function:: nucleic acid binding (GO:0003676)

Date:: 2024-10-16

Family Accession:: NF014342.5
Method:: HMM

Select item 3957704.