Protein Family Models

This family contains a potential peptidoglycan binding domain. [1]. 16155206. COG3926 and COG5526: A tale of two new lysozyme-like protein families. Pei J, Grishin NV;. Protein Sci 2005; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

This family acts as a lysozyme (N-acetylmuramidase), EC:3.2.1.17. It contains a conserved EGGY motif near the N-terminus, the glutamic acid within this motif is essential for catalytic activity [1]. In bacteria, it may activate the secretion of large proteins via the breaking and rearrangement of the peptidoglycan layer during secretion [2,3]. It is frequently found at the N-terminus of proteins containing a C-terminal Pfam:PF09374 domain. [1]. 17174325. Coliphage N4 N-acetylmuramidase defines a new family of murein hydrolases. Stojkovic EA, Rothman-Denes LB;. J Mol Biol. 2007;366:406-419. [2]. 16155206. COG3926 and COG5526: A tale of two new lysozyme-like protein families. Pei J, Grishin NV;. Protein Sci 2005; [Epub ahead of print]. [3]. 7764692. Cloning and characterization of a pair of genes that stimulate the production and secretion of Zymomonas mobilis extracellular levansucrase and invertase. Kondo Y, Toyoda A, Fukushi H, Yanase H, Tonomura K, Kawasaki H, Sakai T;. Biosci Biotechnol Biochem. 1994;58:526-530. (from Pfam)

Date:

2024-10-16

glycoside hydrolase family 108 protein may function as a lysozyme (N-acetylmuramidase), catalyzing the hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

Date:

2021-01-29