Protein Family Models

HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralises this is family HicB, Pfam:PF15919 [1,2,3]. [1]. 16895922. The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria. Makarova KS, Grishin NV, Koonin EV;. Bioinformatics. 2006;22:2581-2584. [2]. 19060138. HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea. Jorgensen MG, Pandey DP, Jaskolska M, Gerdes K;. J Bacteriol. 2009;191:1191-1199. [3]. 21927020. Regulation of growth and death in Escherichia coli by toxin-antitoxin systems. Yamaguchi Y, Inouye M;. Nat Rev Microbiol. 2011;9:779-790. (from Pfam)

Date:

2024-10-16

type II toxin-antitoxin (TA) system HicA family toxin similar to Escherichia coli HicA, part of the HicA-HicB TA module that plays a role in inducing cleavage of mRNA and tmRNA (transfer-mRNA), thereby preventing translation; the hicAB locus is transcribed in response to amino acid and carbon starvation

Date:

2017-06-20