Protein Family Models

This family includes O-antigen polysaccharide polymerases [1]. These enzymes link O-units via a glycosidic linkage to form a long O-antigen [2]. These enzymes vary in specificity and sequence [2]. [1]. 20453897. Escherichia coli serogroup O2 and O28ac O-antigen gene cluster sequences and detection of pathogenic E. coli O2 and O28ac by PCR. Fratamico PM, Yan X, Liu Y, DebRoy C, Byrne B, Monaghan A, Fanning S, Bolton D;. Can J Microbiol. 2010;56:308-316. [2]. 14670712. Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly. Samuel G, Reeves P;. Carbohydr Res. 2003;338:2503-2519. (from Pfam)

Gene:

wzy

Date:

2024-10-16

Members of this subfamily of highly hydrophobic proteins, with few highly conserved residues, all may act to polymerize the oligosaccharide repeat units of surface polysaccharides, including O-antigen in Gram-negative bacteria such as Leptospira (assign gene symbol wzy) and capsular polysaccharide in Gram-positive bacteria such as Streptococcus. O-antigen biosynthesis enzymes produce a repeat unit, usually an oligosaccharide, which itself is polymerized. O-antigen polymerase, usually designated Wzy. This family bears homology to the O-antigen ligase WaaL, but known examples of WaaL fall outside the bounds defined here. This model is much broader than Pfam model PF14296.

Date:

2021-04-27

Gene:

wzy

Date:

2018-01-16