Protein Family Models

This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA, has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration of AI-2, TqsA affects gene expression in biofilms and biofilm formation [1]. TsqA belongs to the AI-2 exporter (AI-2E) superfamily [2]. [1]. 16385049. YdgG (TqsA) controls biofilm formation in Escherichia coli K-12 through autoinducer 2 transport. Herzberg M, Kaye IK, Peti W, Wood TK;. J Bacteriol. 2006;188:587-598. [2]. 20559013. The autoinducer-2 exporter superfamily. Rettner RE, Saier MH Jr;. J Mol Microbiol Biotechnol. 2010;18:195-205. (from Pfam)

Date:

2024-10-16

AI-2E family transporter similar to Escherichia coli PerM and Bacillus subtilis YueF, which may function as permeases

Date:

2023-03-24