Protein Family Models for Protein (Select 446817898) - Protein Family Models

Select item 4250301.

Date:: 2024-08-14

Family Accession:: NF025946.5
Method:: HMM

Select item 4241592.

thioredoxin-like domain-containing protein

Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF025273.5
Method:: HMM

Select item 4230063.

thioredoxin fold domain-containing protein

Date:: 2024-08-14

Family Accession:: NF024498.5
Method:: HMM

Select item 4162494.

OST3 / OST6 family, transporter family

The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs [1]. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation [2]. These proteins are also thought to be novel Mg2+ transporters [3]. [1]. 7622558. Functional characterization of Ost3p. Loss of the 34-kD subunit of the Saccharomyces cerevisiae oligosaccharyltransferase results in biased underglycosylation of acceptor substrates. Karaoglu D, Kelleher DJ, Gilmore R;. J Cell Biol 1995;130:567-577. [2]. 10358084. The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex. Knauer R, Lehle L;. J Biol Chem 1999;274:17249-17256. [3]. 15804357. Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties. Goytain A, Quamme GA;. BMC Genomics. 2005;6:48. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF016631.5
Method:: HMM

Select item 4159505.

thioredoxin domain-containing protein

This is the thioredoxin domain from in Thioredoxin domain-containing protein 17, also known as TRP14, which is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways [1]. This domain is also found at the C-terminal of Acireductone dioxygenase (ARD) from Leishmania. [1]. 15355959. Structural basis of cellular redox regulation by human TRP14. Woo JR, Kim SJ, Jeong W, Cho YH, Lee SC, Chung YJ, Rhee SG, Ryu SE;. J Biol Chem. 2004;279:48120-48125. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF017882.5
Method:: HMM

Select item 4117456.

thioredoxin domain-containing protein

Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF012314.5
Method:: HMM

Select item 4008487.