Protein Family Models

This domain is found in eukaryotic integral membrane proteins. Swiss:Q12239, a Saccharomyces cerervisiae protein, has been shown to localise COP II vesicles [1]. [1]. 14562095. Global analysis of protein localization in budding yeast. Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK;. Nature 2003;425:686-691. (from Pfam)

Date:

2024-10-16

This family contains integral membrane proteins that are related to Drosophila rhomboid protein Swiss:P20350. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease [2][3][4] (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite [5]. [1]. 2110920. rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Bier E, Jan LY, Jan YN;. Genes Dev 1990;4:190-203. [2]. 11672525. Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Urban S, Lee JR, Freeman M;. Cell 2001;107:173-182. [3]. 12620104. The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. Koonin EV, Makarova KS, Rogozin IB, Davidovic L, Letellier MC, Pellegrini L;. Genome Biol 2003;4:R19. [4]. 15684070. Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity. Urban S, Wolfe MS;. Proc Natl Acad Sci U S A. 2005;102:1883-1888. [5]. 15753289. A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma. Brossier F, Jewett TJ, Sibley LD, Urban S;. Proc Natl Acad Sci U S A. 2005;102:4146-4151. (from Pfam)

Date:

2024-10-16

rhomboid family intramembrane serine protease is a membrane-bound protein that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchor

Date:

2024-05-27