Protein Family Models

Date:

2024-08-14

This domain is found at the N terminus of several sigma54- dependent transcriptional activators including PrpR, which activates catabolism of propionate. [1]. 11495997. The methylcitric acid pathway in Ralstonia eutropha: new genes identified involved in propionate metabolism. Bramer CO, Steinbuchel A;. Microbiology 2001;147:2203-2214. [2]. 6051. Enzymatic synthesis of 2-O-alpha-D-mannopyranosyl-methyl-alpha-D-mannopyranoside by a cell-free particulate system of Mycobacterium smegmatis. Schultz JC, Takayama K;. Biochim Biophys Acta 1976;428:563-572. [3]. 12700259. Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol. Palacios S, Starai VJ, Escalante-Semerena JC;. J Bacteriol 2003;185:2802-2810. [4]. 10648513. prpR, ntrA, and ihf functions are required for expression of the prpBCDE operon, encoding enzymes that catabolize propionate in Salmonella enterica serovar typhimurium LT2. Palacios S, Escalante-Semerena JC;. J Bacteriol 2000;182:905-910. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

Date:

2024-08-14

Magnesium-chelatase is a three-component enzyme that catalyses the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa. [1]. 9359397. Mechanism and regulation of Mg-chelatase. Walker CJ, Willows RD;. Biochem J 1997;327:321-333. [2]. 9457877. Reconstitution of an active magnesium chelatase enzyme complex from the bchI, -D, and -H gene products of the green sulfur bacterium Chlorobium vibrioforme expressed in Escherichia coli. Petersen BL, Jensen PE, Gibson LC, Stummann BM, Hunter CN, Henningsen KW;. J Bacteriol 1998;180:699-704. (from Pfam)

Date:

2024-10-16

sigma-54-dependent Fis family transcriptional regulator, similar to propionate catabolism operon regulatory protein PrpR, which has a role in regulating expression of enzymes involved in both glyoxylate and methylcitrate pathways

Date:

2017-03-21

Sigma-54 dependent activator family protein; activates the prpBCDE operon

Gene:

prpR

Date:

2020-10-26

At least five distinct pathways exists for the catabolism of propionate by way of propionyl-CoA. Members of this family represent the transcriptional regulatory protein PrpR, whose gene is found in most cases divergently transcribed from an operon for the methylcitric acid cycle of propionate catabolism. 2-methylcitric acid, a catabolite by this pathway, is a coactivator of PrpR.

Gene:

prpR

Date:

2024-05-15