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type 4 pilus major pilin
Type IV pili are bacterial virulence-associated adhesins that promote bacterial attachment to host cells. In Salmonella typhi, the structural pilin protein PilS interacts with the cystic fibrosis transmembrane conductance regulator [1]. Mutagenesis studies suggest that residues on an alpha-beta loop and the C terminal disulphide-bonded region of PilS might be involved in binding specificity of the pilus [2]. [1]. 14500527. The type IVB pili of Salmonella enterica serovar Typhi bind to. the cystic fibrosis transmembrane conductance regulator.. Tsui IS, Yip CM, Hackett J, Morris C;. Infect Immun. 2003;71:6049-6050.. [2]. 15159389. NMR structure of a type IVb pilin from Salmonella typhi and its. assembly into pilus.. Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK;. J Biol Chem. 2004;279:31599-31605. (from Pfam)
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