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YajR YAM domain
This entry represents the C-terminal domain of YajR, an Escherichia coli transporter that belongs to the major facilitator superfamily. This domain has been termed YAM domain, whose precise regulatory role is not yet known. It may sense environmental changes, such as pH and halogen ion variation [1,2]. Paper describing PDB structure 2ru9. [1]. 24952155. Atomic resolution structure of the E. coli YajR transporter YAM domain. Jiang D, Zhao Y, Fan J, Liu X, Wu Y, Feng W, Zhang XC;. Biochem Biophys Res Commun. 2014;450:929-935. Paper describing PDB structure 3wdo. [2]. 23950222. Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A. Jiang D, Zhao Y, Wang X, Fan J, Heng J, Liu X, Feng W, Kang X, Huang B, Liu J, Zhang XC;. Proc Natl Acad Sci U S A. 2013;110:14664-14669. (from Pfam)
MFS transporter
major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides
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