Protein Family Models

A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine. (from Pfam)

Date:

2024-08-14

This family are hydrolase enzymes. [1]. 1381445. Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2.0 A resolution. Romao MJ, Turk D, Gomis-Ruth FX, Huber R, Schumacher G, Mollering H, Russmann L;. J Mol Biol 1992;226:1111-1130. (from Pfam)

Date:

2024-10-16

(2,3-dihydroxybenzoyl)adenylate synthase catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate via a reversible ATP-dependent pyrophosphate exchange reactions to yield the acyladenylate intermediate (2,3-dihydroxybenzoyl)adenylate, such as in the biosynthesis of the siderophore enterobactin| cysteine hydrolase family protein related to isochorismatase and nicotinamidase; catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue

Date:

2017-03-02