Protein Family Models for Protein (Select 446939140) - Protein Family Models

Select item 4191601.

This is a family of RNA ligases. The enzyme repairs RNA strand breaks in nicked DNA:RNA and RNA:RNA but not in DNA:DNA duplexes. [1]. 17018278. RNA ligase structures reveal the basis for RNA specificity and. conformational changes that drive ligation forward.. Nandakumar J, Shuman S, Lima CD;. Cell. 2006;127:71-84. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF020968.5
Method:: HMM

Select item 4157772.

WGR domain-containing protein

This domain is found in a variety of polyA polymerases as well as the E. coli molybdate metabolism regulator Swiss:P33345 and other proteins of unknown function. I have called this domain WGR after the most conserved central motif of the domain. The domain is found in isolation in proteins such as Swiss:Q9JN21 and is between 70 and 80 residues in length. I propose that this may be a nucleic acid binding domain. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF017243.5
Method:: HMM

Select item 4110733.

ATP dependent DNA ligase domain

This domain belongs to a more diverse superfamily, including Pfam:PF01331 and Pfam:PF01653 [3]. [1]. 8653795. Crystal structure of an ATP-dependent DNA ligase from. bacteriophage T7.. Subramanya HS, Doherty AJ, Ashford SR, Wigley DB;. Cell 1996;85:607-615.. [2]. 9363683. Mammalian DNA ligases.. Tomkinson AE, Levin DS;. Bioessays 1997;19:893-901.. [3]. 10222208. Gleaning non-trivial structural, functional and evolutionary. information about proteins by iterative database searches.. Aravind L, Koonin EV;. J Mol Biol 1999;287:1023-1040. (from Pfam)

GO Terms:

Molecular Function:: DNA ligase (ATP) activity (GO:0003910)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: DNA repair (GO:0006281)

Biological Process:: DNA recombination (GO:0006310)

Date:: 2024-08-14

Family Accession:: NF013252.5
Method:: HMM

Select item 3967634.