Protein Family Models

This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation [2]. This family also includes homoserine kinase. This family is related to fructosamine kinase Pfam:PF03881. [1]. 2163618. Cloning of aminoglycoside phosphotransferase (APH) gene from. antibiotic- producing strain of Bacillus circulans into a. high-expression vector, pKK223-3. Purification, properties and. location of the enzyme [published erratum appears in Biochem J. 1991 Feb 1. Sarwar M, Akhtar M;. Biochem J 1990;268:671-677.. [2]. 2167474. PCR cloning of a streptomycin phosphotransferase (aphE) gene. from Streptomyces griseus ATCC 12475.. Trower MK, Clark KG;. Nucleic Acids Res 1990;18:4615-4615. (from Pfam)

Date:

2024-08-14

Members of this family are aminoglycoside O-phosphotransferases. They modify the 3'' site found in streptomycin, and therefore confer resistance to streptomycin.

Gene:

aph(3'')-Ib

Date:

2022-03-28

aminoglycoside 3'-phosphotransferase phosphorylates and inactives antibiotic substrates such as kanamycin, streptomycin, neomycin, and gentamicin, among others

Date:

2016-05-13

Members of this family confer resistance to streptomycin, an aminoglycoside, but catalyzing a modification to 3'' prime position.

Date:

2020-11-23