Protein Family Models

This family consists of the LuxS protein involved in autoinducer AI2 synthesis and its hypothetical relatives. S-ribosylhomocysteinase (LuxS) catalyses the cleavage of the thioether bond in S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of type II bacterial quorum sensing molecule. [1]. 9990077. Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Surette MG, Miller MB, Bassler BL;. Proc Natl Acad Sci U S A 1999;96:1639-1644. [2]. 15287744. Catalytic mechanism of S-ribosylhomocysteinase (LuxS): stereochemical course and kinetic isotope effect of proton transfer reactions. Zhu J, Patel R, Pei D;. Biochemistry 2004;43:10166-10172. [3]. 14583032. Catalytic mechanism of S-ribosylhomocysteinase (LuxS): direct observation of ketone intermediates by 13C NMR spectroscopy. Zhu J, Hu X, Dizin E, Pei D;. J Am Chem Soc 2003;125:13379-13381. [4]. 12705835. S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein. Zhu J, Dizin E, Hu X, Wavreille AS, Park J, Pei D;. Biochemistry 2003;42:4717-4726. (from Pfam)

Date:

2024-10-16

S-ribosylhomocysteine lyase catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD), which spontaneously cyclizes and combines with borate to form autoinducer (AI-2)

Date:

2023-02-28

Gene:

luxS

Date:

2020-10-26